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Feb 09

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Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain

Ganzel, B.L, Kim, P. Glover, P.H., and Temple, E. (2008)

Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain

 

Neuroimage. 2008 April 1; 40(2): 788–795.

 

Published online 2008 January 29. doi: 10.1016/j.neuroimage.2007.12.010

 

Abstract

 

Exposure to psychological trauma is common and predicts long-term physical and mental health problems, even in those who initially appear resilient. Here, we used multimodal neuroimaging in healthy adults who were at different distances from the World Trade Center on 9/11/01 to examine the neural mechanisms that may underlie this association. More than three years after 9/11/01, adults with closer proximity to the disaster had lower gray matter volume in amygdala, hippocampus, insula, anterior cingulate, and medial prefrontal cortex, with control for age, gender, and total gray matter volume. Further analysis showed a nonlinear (first-order quadratic) association between total number of traumas in lifetime and amygdala gray matter volume and function in the whole group. Post hoc analysis of subgroups with higher versus lower levels of lifetime trauma exposure revealed systematic associations between amygdala gray matter volume, amygdala functional reactivity, and anxiety that suggest a nonlinear trajectory in the neural response to accumulated trauma in healthy adults.

 

To read the paper click here

 

Permanent link to this article: http://hart2heart.co.uk/resilience-after-911

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